Central Sensitization

A spinal analog of memory reconsolidation enables reversal of hyperalgesia.


A Subgroup of Chronic Low Back Pain Patients With Central Sensitization.

Aoyagi K, He J, Nicol AL, Clauw DJ, Kluding PM, Jernigan S, Sharma NK. Clin J Pain. 2019 Nov;35(11):869-879. doi: 10.1097/AJP.0000000000000755.

Alterations in temporal summation of pain and conditioned pain modulation across an episode of experimental exercise-induced low back pain.

McPhee M, Graven-Nielsen T. J Pain. 2018 Sep 17. pii: S1526-5900(18)30579-0. doi: 10.1016/j.jpain.2018.08.010.

Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain.


Applying modern pain neuroscience in clinical practice: criteria for the classification of central sensitization pain.


Are signs of central sensitisation in acute low back pain a precursor to poor outcome?

David M. Klyne, G. Lorimer Moseley, Michele Sterling, Mary F. Barbe, Paul W. Hodges. The Journal of Pain. 7 March 2019. DOI: 10.1016/j.jpain.2019.03.001

Assessment and manifestation of central sensitisation across different chronic pain conditions

Arendt-Nielsen, B. Morlion, S. Perrot, A. Dahan, A. Dickenson, H.G. Kress, C. Wells, D. Bouhassira and A. Mohr Drewes. European Journal of Pain. 5 NOV 2017. DOI: 10.1002/ejp.1140

Association between pain, central sensitization and anxiety in postherpetic neuralgia.


Beyond nociception: the imprecision hypothesis of chronic pain.


Central sensitization and changes in conditioned pain modulation in people with chronic nonspecific low back pain: a case-control study.


Central Sensitization and Neuropathic Features of Ongoing Pain in a Rat Model of Advanced Osteoarthritis.


Central sensitization as the mechanism underlying pain in joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.

Di Stefano G, Celletti C, Baron R, Castori M, Di Franco M, La Cesa S, Leone C, Pepe A, Cruccu G, Truini A, Camerota F. Eur J Pain. 2016 Sep

Central sensitization of the spino-parabrachial-amygdala pathway that outlasts a brief nociceptive stimulus.

Kissiwaa SA, Bagley EE. J Physiol. 2018 Jul 13. doi: 10.1113/JP273976.

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity


Central sensitization: implications for the diagnosis and treatment of pain.

Woolf CJ.Pain. 2011 Mar

Central sensitization: Nice to know?

Michele Curatolo. European Journal of Pain. 21 NOV 2017. DOI: 10.1002/ejp.1154

Changing Balance of Spinal Cord Excitability and Nociceptive Brain Activity in Early Human Development.

Hartley C, Moultrie F, Gursul D, Hoskin A, Adams E, Rogers R, Slater R. Curr Biol. 2016 Jun

Chronic cervical radiculopathic pain is associated with increased excitability and hyperpolarization-activated current ( Ih) in large-diameter dorsal root ganglion neurons.

Liu DL, Wang X, Chu WG, Lu N, Han WJ, Du YK, Hu SJ, Bai ZT, Wu SX, Xie RG, Luo C. Mol Pain. 2017 Jan-Dec;13:1744806917707127. doi: 10.1177/1744806917707127.

Clinical descriptors for the recognition of central sensitization pain in patients with knee osteoarthritis.

Lluch E, Nijs J, Courtney CA, Rebbeck T, Wylde V, Baert I, Wideman TH, Howells N, Skou ST. Disabil Rehabil. 2017 Aug 2:1-10. doi: 10.1080/09638288.2017.1358770.

Contrasting alterations to synaptic and intrinsic properties in upper-cervical superficial dorsal horn neurons following acute neck muscle inflammation


Establishing Clinically Relevant Severity Levels for the Central Sensitization Inventory.

Neblett R, Hartzell MM, Mayer TG, Cohen H, Gatchel RJ. Pain Pract. 2016 Mar 15

Evidence for central sensitization in patients with osteoarthritis pain: a systematic literature review.


Evidence for Central Sensitization in Patients with Temporomandibular Disorders: A Systematic Review and Meta-analysis of Observational Studies.

La Touche R, Paris-Alemany A, Hidalgo-Pérez A, López-de-Uralde-Villanueva I, Angulo-Diaz-Parreño S, Muñoz-García D. Pain Pract. 2017 May 29. doi: 10.1111/papr.12604.

Experimentally induced central sensitization in the cervical spine evokes postural stiffening strategies in healthy young adults.


Gain control mechanisms in the nociceptive system.

Treede RD. Pain. 2016 Jun

In the spine or in the brain? Recent advances in pain neuroscience applied in the intervention for low back pain.

Nijs J, Clark J, Malfliet A, Ickmans K, Voogt L, Don S, den Bandt H, Goubert D, Kregel J, Coppieters I, Dankaerts W. Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 107(5):108-115.

Is there a causal relationship between acute stage sensorimotor cortex activity and the development of chronic low back pain? a protocol and statistical analysis plan.

Jenkins L, Chang WJ, Buscemi V, Cunningham C, Cashin A, McAuley JH, Liston M, Schabrun SM. BMJ Open. 2019 Dec 29;9(12):e035792. doi: 10.1136/bmjopen-2019-035792.

Lack of evidence for central sensitization in idiopathic, non-traumatic neck pain: a systematic review.


Mechanisms of central sensitization, neuroimmunology & injury biomechanics in persistent pain: implications for musculoskeletal disorders.


Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.

Ji RR, Nackley A, Huh Y, Terrando N, Maixner W. Anesthesiology. 2018 Feb 19. doi: 10.1097/ALN.0000000000002130.

Neuronal hyperexcitability in the dorsal horn after painful facet joint injury.

Quinn KP, Dong L, Golder FJ, Winkelstein BA. Pain. 2010 Nov;151(2):414-21. doi: 10.1016/j.pain.2010.07.034.

Nociceptive phenotype alterations of dorsal root ganglia neurons innervating the subchondral bone in osteoarthritic rat knee joints.

Aso K, Izumi M, Sugimura N, Okanoue Y, Ushida T, Ikeuchi M. Osteoarthritis Cartilage. 2016 Apr 13

Notch signaling activation is critical to the development of neuropathic pain


Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity.

Collins KH, Herzog W, MacDonald GZ, Reimer RA, Rios JL, Smith IC, Zernicke RF, Hart DA. Front Physiol. 2018 Feb 23;9:112. doi: 10.3389/fphys.2018.00112.

Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model.


Persistent Pain after Spinal Cord Injury Is Maintained by Primary Afferent Activity


Phenotypic Features of Central Sensitization.

Williams DA. J Appl Biobehav Res. 2018 Jun;23(2). pii: e12135. doi: 10.1111/jabr.12135.

Phenotypic Features of Central Sensitization.

Williams DA. J Appl Biobehav Res. 2018 Jun;23(2). pii: e12135. doi: 10.1111/jabr.12135.

Psychological distress and widespread pain contribute to the variance of the central sensitization inventory: A cross-sectional study in patients with chronic pain.

van Wilgen CP, Vuijk PJ, Kregel J, Voogt L, Meeus M, Descheemaker F, Keizer D, Nijs J. Pain Pract. 2017 Apr 27. doi: 10.1111/papr.12600.

Recognition of central sensitization in patients with musculoskeletal pain: Application of pain neurophysiology in manual therapy practice.

Nijs J, Van Houdenhove B, Oostendorp RA. Man Ther. 2010 Apr;15(2):135-41. doi: 10.1016/j.math.2009.12.001

Somatic syndromes and chronic pain in women with overactive bladder.

Reynolds WS, Mock S, Zhang X, Kaufman M, Wein A, Bruehl S, Dmochowski R. Neurourol Urodyn. 2016 Jul

Spinal Stimulation for Pain: Future Applications


Sustained neurochemical plasticity in central terminals of mouse DRG neurons following colitis.


Sympathectomy and Sympathetic Blockade Reduce Pain Behavior Via Alpha-2 Adrenoceptor of the Dorsal Root Ganglion Neurons in a Lumbar Radiculopathy Model.


The central sensitization inventory predict pain-related disability for musculoskeletal disorders in the primary care setting.

Tanaka K, Murata S, Nishigami T, Mibu A, Manfuku M, Shinohara Y, Tanabe A, Ono R. Eur J Pain. 2019 Jun 24. doi: 10.1002/ejp.1443.

The neurobiology of central sensitization

Steven E. Harte, Richard E. Harris, Daniel J. Clauw. Journal of Applied Biobehavioral Research. Volume 23, Issue 2. 27 June 2018. DOI: 10.1111/jabr.12137

The neurobiology of central sensitization

Steven E. Harte, Richard E. Harris. Daniel J. Clauw. Journal of Applied Biobehavioral Research. 27 June 2018. Doi:10.1111/jabr.12137

The role of the dorsal root ganglion in the development of neuropathic pain.


The transition from naïve to primed nociceptive state: A novel wind-up protocol in mice.


Trait Sensitivity, Anxiety, and Personality Are Predictive of Central Sensitization Symptoms in Patients with Chronic Low Back Pain.

Clark JR, Nijs J, Yeowell G, Holmes P, Goodwin PC. Pain Pract. 2019 Jun 19. doi: 10.1111/papr.12809.

Treatment of central sensitization in patients with chronic pain: time for change?

Nijs J, Leysen L, Vanlauwe J, Logghe T, Ickmans K, Polli A, Malfliet A, Coppieters I, Huysmans E. Expert Opin Pharmacother. 2019 Jul 29:1-10. doi: 10.1080/14656566.2019.1647166.

Up to a quarter of patients with certain chronic recalcitrant tendinopathies may have central sensitisation: a prospective cohort of more than 300 patients

Patrick C Wheeler. British Journal of Pain. September 21, 2018. Doi: 10.1177/2049463718800352

Use of the central sensitization inventory (CSI) as a treatment outcome measure for chronic spinal pain disorder patients in a functional restoration program.

Neblett R, Hartzell MM, Williams M, Bevers KR, Mayer TG, Gatchel RJ. Spine J. 2017 Jun 12. pii: S1529-9430(17)30270-X. doi: 10.1016/j.spinee.2017.06.008.

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