Descending Modulation of Pain

A Neural Circuit for the Suppression of Pain by a Competing Need State.

Alhadeff AL, Su Z, Hernandez E, Klima ML, Phillips SZ, Holland RA, Guo C, Hantman AW, De Jonghe BC, Betley JN. Cell. 2018 Mar 22;173(1):140-152.e15. doi: 10.1016/j.cell.2018.02.057.

Descending Control Mechanisms and Chronic Pain.

Chen Q, Heinricher MM. Curr Rheumatol Rep. 2019 Mar 4;21(5):13. doi: 10.1007/s11926-019-0813-1. Review.

Descending controls modulate inflammatory joint pain and regulate CXC chemokine and iNOS expression in the dorsal horn

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080690

Descending Facilitation Maintains Long-term Spontaneous Neuropathic Pain

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028636/?tool=pmcentrez

Descending Systems Direct Development of Key Spinal Motor Circuits.

Smith CC, Paton JFR, Chakrabarty S, Ichiyama RM. J Neurosci. 2017 Jun 28;37(26):6372-6387. doi: 10.1523/JNEUROSCI.0149-17.2017.

Expectations modulate heterotopic noxious counter-stimulation analgesia.

http://www.ncbi.nlm.nih.gov/pubmed/23260452

Low Back Pain: The Potential Contribution of Supraspinal Motor Control and Proprioception.

Meier ML, Vrana A, Schweinhardt P. Neuroscientist. 2018 Nov 2:1073858418809074. doi: 10.1177/1073858418809074.

Low Back Pain: The Potential Contribution of Supraspinal Motor Control and Proprioception.

Meier ML, Vrana A, Schweinhardt P.n Neuroscientist. 2018 Nov 2:1073858418809074. doi: 10.1177/1073858418809074.

Modification of Descending Analgesia in Aging: Critical Role of the Prefrontal Cortex.

Lithfous S, Després O, Pebayle T, Dufour A. Clin J Pain. 2018 Sep 15. doi: 10.1097/AJP.0000000000000655.

Pain Inhibits Pain: an Ascending-Descending Pain Modulation Pathway Linking Mesolimbic and Classical Descending Mechanisms.

Tobaldini G, Sardi NF, Guilhen VA, Fischer L. Mol Neurobiol. 2018 Jun 1. doi: 10.1007/s12035-018-1116-7.

Representation of spatial information in key areas of the descending pain modulatory system.

http://www.ncbi.nlm.nih.gov/pubmed/24672009

Temporal Filtering of Nociceptive Information by Dynamic Activation of Endogenous Pain Modulatory Systems

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739444/?tool=pmcentrez

The role of descending inhibitory pathways on chronic pain modulation and clinical implications.

http://www.ncbi.nlm.nih.gov/pubmed/24256177

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