Medication

A systematic review of the evidence for the efficacy of opioids for chronic non-cancer pain in community-dwelling older adults.

O’Brien MDC, Wand APF. Age Ageing. 2020 Jan 23. pii: afz175. doi: 10.1093/ageing/afz175.

Adverse Effects of Antidepressants for Chronic Pain: A Systematic Review and Meta-analysis.

Riediger C, Schuster T, Barlinn K, Maier S, Weitz J, Siepmann T. Front Neurol. 2017 Jul 14;8:307. doi: 10.3389/fneur.2017.00307.

Adverse event reporting in clinical trials of intravenous and invasive pain treatments: An ACTTION systematic review.

Williams MR, McKeown A, Pressman Z, Hunsinger M, Lee K, Coplan P, Gilron I, Katz NP, McDermott MP, Raja SN, Rappaport BA, Rowbotham MC, Turk DC, Dworkin RH, Smith SM. J Pain. 2016 Aug

Aspirin for acute treatment of episodic tension-type headache in adults.

Derry S, Wiffen PJ, Moore RA. Cochrane Database Syst Rev. 2017 Jan 13;1:CD011888. doi: 10.1002/14651858.CD011888.pub2.

Association Between Utilization of Chiropractic Services for Treatment of Low-Back Pain and Use of Prescription Opioids.

Whedon JM, Toler AWJ, Goehl JM, Kazal LA. J Altern Complement Med. 2018 Feb 22. doi: 10.1089/acm.2017.0131.

Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, and violent crime: population based cohort study in Sweden.

Molero Y, Larsson H, D’Onofrio BM, Sharp DJ, Fazel S. BMJ. 2019 Jun 12;365:l2147. doi: 10.1136/bmj.l2147.

Avoid routinely prescribing medicines for non-specific low back pain.

Traeger AC, Buchbinder R, Harris IA, Clavisi OM, Maher CG. Br J Sports Med. 2018 Mar 7. pii: bjsports-2017-098614. doi: 10.1136/bjsports-2017-098614.

Barriers and enablers to monitoring and deprescribing opioid analgesics for chronic non-cancer pain: protocol for a qualitative evidence synthesis using the Theoretical Domains Framework.

Cross AJ, Buchbinder R, Bourne A, Maher C, Mathieson S, Lin CC, O’Connor DA. BMJ Open. 2019 Nov 12;9(11):e034039. doi: 10.1136/bmjopen-2019-034039.

Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials.

Shanthanna H, Gilron I, Rajarathinam M, AlAmri R, Kamath S, Thabane L, Devereaux PJ, Bhandari M. PLoS Med. 2017 Aug 15;14(8):e1002369. doi: 10.1371/journal.pmed.1002369.

Cervical Facet Joint Imaging-Guided Injections: A Comparison of Outcomes in Patients Referred Based on Imaging Findings vs Palpation for Pain.

Le Clec’h Y, Peterson CK, Brunner F, Pfirrmann CW. J Manipulative Physiol Ther. 2016 Aug

Combination drug therapy for the management of low back pain and sciatica; systematic review and meta-analysis

Dr Stephanie Mathieson, Dr Richard Kasch, Professor Christopher G. Maher, Dr Rafael Zambelli Pinto, Professor Andrew J. McLachlan, Professor Bart W. Koes, Associate Professor Chung-Wei Christine Lin. The Journal of Pain. July 2, 2018. DOI: 10.1016/j.jpain.2018.06.005

Compounded Topical Pain Creams to Treat Localized Chronic Pain: A Randomized Controlled Trial.

Brutcher RE, Kurihara C, Bicket MC, Moussavian-Yousefi P, Reece DE, Solomon LM, Griffith SR, Jamison DE, Cohen SP. Ann Intern Med. 2019 Feb 5. doi: 10.7326/M18-2736.

Cost-effectiveness analysis of the pharmacological management of chronic low back pain with four leading drugs.

Kaito T, Matsuyama Y, Mochida J, et al; Project Committee of the Japanese Society for Spine Surgery and Related Research (JSSR). J Orthop Sci. 2019 Jun 20. pii: S0949-2658(19)30185-X. doi: 10.1016/j.jos.2019.06.004.

Diazepam Is No Better Than Placebo When Added to Naproxen for Acute Low Back Pain.

Friedman BW, Irizarry E, Solorzano C, Khankel N, Zapata J, Zias E, Gallagher EJ. Ann Emerg Med. 2017 Jan 19. pii: S0196-0644(16)31214-8. doi: 10.1016/j.annemergmed.2016.10.002.

Drugs associated with adverse events in children and adolescents.

http://www.ncbi.nlm.nih.gov/pubmed/24990656

Effect of NSAIDs on Bone Healing Rates: A Meta-analysis.

Wheatley BM, Nappo KE, Christensen DL, Holman AM, Brooks DI, Potter BK. J Am Acad Orthop Surg. 2019 Apr 1;27(7):e330-e336. doi: 10.5435/JAAOS-D-17-00727.

Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial.

Krebs EE, Gravely A, Nugent S, Jensen AC, DeRonne B, Goldsmith ES, Kroenke K, Bair MJ, Noorbaloochi S. JAMA. 2018 Mar 6;319(9):872-882. doi: 10.1001/jama.2018.0899.

Efficacy and tolerability of muscle relaxants for low back pain: Systematic review and meta-analysis.

Abdel Shaheed C, Maher CG, Williams KA, McLachlan AJ. Eur J Pain. 2016 Jun 22

Efficacy of paracetamol, diclofenac and advice for acute low back pain in general practice: design of a randomized controlled trial (PACE Plus).

Schreijenberg M, Luijsterburg PA, Van Trier YD, Rizopoulos D, Koopmanschap MA, Voogt L, Maher CG, Koes BW. BMC Musculoskelet Disord. 2017 Feb 1;18(1):56. doi: 10.1186/s12891-017-1432-5.

Eighty years of Medication-Overuse Headache: what about Medication-Overuse Backpain?

Luchting B, Heyn J. J Neurol. 2019 Dec;266(12):3167-3170. doi: 10.1007/s00415-019-09611-7.

Exposure to antibiotics in the first 24 months of life and neurocognitive outcomes at 11 years of age.

Slykerman RF, Coomarasamy C, Wickens K, Thompson JMD, Stanley TV, Barthow C, Kang J, Crane J, Mitchell EA. Psychopharmacology (Berl). 2019 May;236(5):1573-1582. doi: 10.1007/s00213-019-05216-0.

Factors Associated With High-Quality Guidelines for the Pharmacologic Management of Chronic Diseases in Primary Care: A Systematic Review.

Molino CGRC, Leite-Santos NC, Gabriel FC, Wainberg SK, Vasconcelos LP, Mantovani-Silva RA, Ribeiro E, Romano-Lieber NS, Stein AT, Melo DO; Chronic Diseases and Informed Decisions (CHRONIDE) Group. JAMA Intern Med. 2019 Feb 18. doi: 10.1001/jamainternmed.2018.7529.

Harms and benefits of opioids for management of non-surgical acute and chronic low back pain: a systematic review.

Tucker HR, Scaff K, McCloud T, Carlomagno K, Daly K, Garcia A, Cook CE. Br J Sports Med. 2019 Mar 22. pii: bjsports-2018-099805. doi: 10.1136/bjsports-2018-099805.

Impact of Chiropractic Care on Use of Prescription Opioids in Patients with Spinal Pain.

Whedon JM, Toler AWJ, Kazal LA, Bezdjian S, Goehl JM, Greenstein J. Pain Med. 2020 Mar 6. pii: pnaa014. doi: 10.1093/pm/pnaa014.

Impact of potential inappropriate NSAIDs use in chronic pain

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403601/?tool=pmcentrez

Investigation of a possible association of potentially inappropriate medication for older adults and frailty in a prospective cohort study from Germany.

Muhlack DC, Hoppe LK, Saum KU, Haefeli WE, Brenner H, Schöttker B. Age Ageing. 2019 Dec 1;49(1):20-25. doi: 10.1093/ageing/afz127.

Medicate or Meditate? Greater Pain Acceptance is Related to Lower Pain Medication Use in Persons with Chronic Pain and Spinal Cord Injury.

Kratz AL, Murphy J 3rd, Kalpakjian CZ, Chen P. Clin J Pain. 2017 Sep 4. doi: 10.1097/AJP.0000000000000550.

New problems arising from old drugs: second-generation effects of acetaminophen.

http://www.ncbi.nlm.nih.gov/pubmed/25075430

Non-steroidal anti-inflammatory drugs for spinal pain: a systematic review and meta-analysis

Gustavo C Machado, Chris G Maher, Paulo H Ferreira, Richard O Day, Marina B Pinheiro, Manuela L Ferreira Ann Rheum Dis Published Online First: 2 February 2017 doi:10.1136/annrheumdis-2016-210597

NSAID use in intervertebral disc degeneration: what are the effects on matrix homeostasis in vivo?

Vaudreuil N, Kadow T, Yurube T, Hartman R, Ngo K, Dong Q, Pohl P, Coelho JP, Kang J, Vo N, Sowa G. Spine J. 2017 Apr 14. pii: S1529-9430(17)30146-8. doi: 10.1016/j.spinee.2017.04.012

Opioids for chronic osteoarthritis pain. An updated systematic review and meta-analysis of efficacy, tolerability and safety in randomized placebo-controlled studies of at least four weeks double-blind duration.

Welsch P, Petzke F, Klose P, Häuser W. Eur J Pain. 2019 Dec 26. doi: 10.1002/ejp.1522.

PACE – the first placebo controlled trial of paracetamol for acute low back pain: statistical analysis plan

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750911

Paracetamol (acetaminophen) for acute treatment of episodic tension-type headache in adults.

Stephens G, Derry S, Moore RA. Cochrane Database Syst Rev. 2016 Jun

Paracetamol is ineffective for acute low back pain even for patients who comply with treatment: complier average causal effect analysis of a randomized controlled trial.

Schreijenberg M, Christine Lin CW, McLachlan AJ, Williams CM, Kamper SJ, Koes BW, Maher CG, Billot L. Pain. 2019 Aug 23. doi: 10.1097/j.pain.0000000000001685.

Paracetamol: mechanism of action, applications and safety concern.

http://www.ncbi.nlm.nih.gov/pubmed/24779190

Pregabalin and gabapentin for pain

Stephanie Mathieson, Chung-Wei Christine Lin, Martin Underwood, Sam Eldabe. BMJ 2020;369:m1315. 28 April 2020. doi: 10.1136/bmj.m1315

Prescription of Long-Acting Opioids and Mortality in Patients With Chronic Noncancer Pain.

Ray WA, Chung CP, Murray KT, Hall K, Stein CM. JAMA. 2016 Jun

Primary care physicians’ attitude and reported prescribing behavior for chronic low back pain: An exploratory cross-sectional study.

Rodondi PY, Dubois J, Bill AS, Koutaïssoff D, Ros J, Aveni E, Pasquier J, Herzig L, Decosterd I, Burnand B. PLoS One. 2018 Sep 27;13(9):e0204613. doi: 10.1371/journal.pone.0204613.

Quantifying the impact of NSAID-associated adverse events.

Fine M. Am J Manag Care. 2013 Nov;19(14 Suppl):s267-72.

Regular use of medication for musculoskeletal pain and risk of long-term sickness absence: A prospective cohort study among the general working population.

Sundstrup E, Jakobsen MD, Thorsen SV, Andersen LL. Eur J Pain. 2016 Aug 26. doi: 10.1002/ejp.932.

Regular use of medication for musculoskeletal pain and risk of long-term sickness absence: A prospective cohort study among the general working population.

Sundstrup E, Jakobsen MD, Thorsen SV, Andersen LL. Eur J Pain. 2016 Aug 26. doi: 10.1002/ejp.932.

Reviews may overestimate the effectiveness of medicines for back pain: systematic review and meta-analysis

Matthew K. Bagg, Edel O’Hagan, Pauline Zahara, Benedict M. Wand, Markus Hübscher, G Lorimer Moseley, James H. McAuley. Journal of Clinical Epidemiology. December 6, 2019. DOI: 10.1016/j.jclinepi.2019.12.006

Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data.

Bally M, Dendukuri N, Rich B, Nadeau L, Helin-Salmivaara A, Garbe E, Brophy JM. BMJ. 2017 May 9;357:j1909. doi: 10.1136/bmj.j1909.

Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data.

Bally M, Dendukuri N, Rich B, Nadeau L, Helin-Salmivaara A, Garbe E, Brophy JM. BMJ. 2017 May 9;357:j1909. doi: 10.1136/bmj.j1909.

Safety Considerations in Prescription of NSAIDs for Musculoskeletal Pain: A Narrative Review.

Hatt KM, Vijapura A, Maitin I, Cruz E. PM R. 2018 Jun 28. pii: S1934-1482(18)30361-7. doi: 10.1016/j.pmrj.2018.06.011.

Supporting medication discontinuation: provider preferences for interventions to facilitate deprescribing

Amy Linsky, Mark Meterko, Kelly Stolzmann and Steven R. Simon. BMC Health Services Research. 28 June 2017. DOI: 10.1186/s12913-017-2391-0

System Dynamics to Investigate Opioid Use and Chiropractic Care for Chronic Musculoskeletal Pain.

McGregor M, Nielsen A, Chung C, Fillery MD, Wakeland W, Mior S. J Manipulative Physiol Ther. 2019 Jun 17. pii: S0161-4754(17)30359-7. doi: 10.1016/j.jmpt.2018.11.007.

Systematic Review of the Efficacy and Safety of Gabapentin and Pregabalin for Pain in Children and Adolescents.

Egunsola O, Wylie CE, Chitty KM, Buckley NA. Anesth Analg. 2018 Nov 16. doi: 10.1213/ANE.0000000000003936.

The content validation of the self-reported misuse, abuse and diversion (SR-MAD) of prescription opioids instrument for use in patients with acute or chronic pain.

Setnik B, Roland CL, Barsdorf AI, Brooks A, Coyne KS. Curr Med Res Opin. 2017 Feb 25:1-20. doi: 10.1080/03007995.2017.1300142.

Tramadol for osteoarthritis.

Toupin April K, Bisaillon J, Welch V, Maxwell LJ, Jüni P, Rutjes AW, Husni ME, Vincent J, El Hindi T, Wells GA, Tugwell P. Cochrane Database Syst Rev. 2019 May 27;5:CD005522. doi: 10.1002/14651858.CD005522.pub3.

Tramadol prescribed use in general and chronic noncancer pain: a nationwide register-based cohort study of all patients above 16 years.

Hansen CA, Ernst MT, Stougaard M, Abrahamsen B. Scand J Pain. 2019 Sep 17. pii: /j/sjpain.ahead-of-print/sjpain-2019-0114/sjpain-2019-0114.xml. doi: 10.1515/sjpain-2019-0114.

Trends in Prescription Analgesic Use Among Adults With Musculoskeletal Conditions in the United States, 1999-2016.

Stokes A, Berry KM, Hempstead K, Lundberg DJ, Neogi T. JAMA Netw Open. 2019 Dec 2;2(12):e1917228. doi: 10.1001/jamanetworkopen.2019.17228.

What proportion of patients with chronic noncancer pain are prescribed an opioid medicine? Systematic review and meta-regression of observational studies.

Mathieson S, Wertheimer G, Maher CG, Christine Lin CW, McLachlan AJ, Buchbinder R, Pearson SA, Underwood M. J Intern Med. 2020 Feb 25. doi: 10.1111/joim.13026.

Worsening trends in analgesics recommended for spinal pain in primary care.

Mathieson S, Valenti L, Maher CG, Britt H, Li Q, McLachlan AJ, Lin CC. Eur Spine J. 2017 Jun 21. doi: 10.1007/s00586-017-5178-4.

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