Altered Primary Motor Cortex Structure, Organisation and Function in Chronic Pain: a Systematic Review and Meta-Analysis

Wei-Ju Chang, Neil E. O’Connell, Paula R. Beckenkamp, Ghufran Alhassani, Matthew B. Liston, Siobhan M. Schabrun. Journal of Pain. November 15, 2017. DOI:10.1016/j.jpain.2017.10.007

Are functional brain alterations present in low back pain? A systematic review of EEG studies

Stijn Schouppe, Sophie Van Oosterwijck, Lieven Danneels, Stefaan Van Damme, Jessica Van Oosterwijck. The Journal of Pain. June 28, 2019. DOI: 10.1016/j.jpain.2019.06.010

Chronic non-cancer pain is not associated with accelerated brain aging as assessed by structural MRI in patients treated in specialized outpatient clinics.

Sörös P, Bantel C. Pain. 2019 Nov 18. doi: 10.1097/j.pain.0000000000001756.

Comparison of brain structure between pain-susceptible and asymptomatic individuals following experimental induction of low back pain

Jeff Boissoneault, Charles W Penza, Steven Z George, Michael E Robinson, Mark D Bishop. The Spine Journal. August 31, 2019. DOI: 10.1016/j.spinee.2019.08.015

Corticomotor depression is associated with higher pain severity in the transition to sustained pain: a longitudinal exploratory study of individual differences.

Seminowicz DA, Thapa T, Schabrun SM. J Pain. 2019 Jun 12. pii: S1526-5900(19)30744-8. doi: 10.1016/j.jpain.2019.06.005.

Functional and structural alterations in the migraine cerebellum.

Mehnert J, May A. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17722109. doi: 10.1177/0271678X17722109.

Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI.

Broadhouse KM, Singh MF, Suo C, Gates N, Wen W, Brodaty H, Jain N, Wilson GC, Meiklejohn J, Singh N, Baune BT, Baker M, Foroughi N, Wang Y, Kochan N, Ashton K, Brown M, Li Z, Mavros Y, Sachdev PS, Valenzuela MJ. Neuroimage Clin. 2020 Jan 14;25:102182. doi: 10.1016/j.nicl.2020.102182.

In the spine or in the brain? Recent advances in pain neuroscience applied in the intervention for low back pain.

Nijs J, Clark J, Malfliet A, Ickmans K, Voogt L, Don S, den Bandt H, Goubert D, Kregel J, Coppieters I, Dankaerts W. Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 107(5):108-115.

Is neuroplasticity in the central nervous system the missing link to our understanding of chronic musculoskeletal disorders?

Is the Organisation of the Primary Motor Cortex in Low Back Pain Related to Pain, Movement and/or Sensation?

Elgueta-Cancino E, Schabrun S, Hodges P. Clin J Pain. 2017 Jul 17. doi: 10.1097/AJP.0000000000000535.

Is Traumatic and Non-Traumatic Neck Pain Associated with Brain Alterations? – A Systematic Review.

DePauw R, Coppieters I, Meeus M, Caeyenberghs K, Danneels L, Cagnie B. Pain Physician. 2017 May;20(4):245-260.

MRI evidence of brain atrophy, white matter damage, and functional adaptive changes in patients with cervical spondylosis and prolonged spinal cord compression.

Bernabéu-Sanz Á, Mollá-Torró JV, López-Celada S, Moreno López P, Fernández-Jover E. Eur Radiol. 2019 Jul 26. doi: 10.1007/s00330-019-06352-z.

Neuroplasticity of Supraspinal Structures Associated with Pathological Pain.

Boadas-Vaello P, Homs J, Reina F, Carrera A, Verdú E. Anat Rec (Hoboken). 2017 Aug;300(8):1481-1501. doi: 10.1002/ar.23587.

Peripheral and central alterations affecting spinal nociceptive processing and pain at adulthood in rats exposed to neonatal maternal deprivation.

Juif PE, Salio C, Zell V, Melchior M, Lacaud A, Petit-Demouliere N, Ferrini F, Darbon P, Hanesch U, Anton F, Merighi A, Lelièvre V, Poisbeau P. Eur J Neurosci. 2016 Jun

Physical Exercise as an Epigenetic Modulator of Brain Plasticity and Cognition.

Fernandes J, Arida RM, Gomez-Pinilla F. Neurosci Biobehav Rev. 2017 Jun 27. pii: S0149-7634(17)30149-5. doi: 10.1016/j.neubiorev.2017.06.012.

Revisiting the Corticomotor Plasticity in Low Back Pain: Challenges and Perspectives.

Massé-Alarie H, Schneider C. Healthcare (Basel). 2016 Sep 8;4(3). pii: E67. doi: 10.3390/healthcare4030067

Self-Organization of Microcircuits in Networks of Spiking Neurons with Plastic Synapses

Simultaneous Brain-Cervical Cord fMRI Reveals Intrinsic Spinal Cord Plasticity during Motor Sequence Learning.

Vahdat S, Lungu O, Cohen-Adad J, Marchand-Pauvert V, Benali H, Doyon J. PLoS Biol. 2015 Jun 30;13(6):e1002186. doi: 10.1371/journal.pbio.1002186.

Simultaneous Brain–Cervical Cord fMRI Reveals Intrinsic Spinal Cord Plasticity during Motor Sequence Learning

Structural network differences in chronic muskuloskeletal pain: Beyond fractional anisotropy.

Bishop JH, Shpaner M, Kubicki A, Clements S, Watts R, Naylor MR. Neuroimage. 2017 Dec 11. pii: S1053-8119(17)31043-1. doi: 10.1016/j.neuroimage.2017.12.021.

Sympathetic regulation and anterior cingulate cortex volume are altered in a rat model of chronic back pain.

Touj S, Houle S, Ramla D, Jeffrey-Gauthier R, Hotta H, Bronchti G, Martinoli MG, Piché M. Neuroscience. 2017 Apr 4. pii: S0306-4522(17)30222-1. doi: 10.1016/j.neuroscience.2017.03.047.

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain.

Bliss TV, Collingridge GL, Kaang BK, Zhuo M. Nat Rev Neurosci. 2016 Jun

The Brain Is Needed to Cure Spinal Cord Injury.

Isa T. Trends Neurosci. 2017 Sep 8. pii: S0166-2236(17)30154-6. doi: 10.1016/j.tins.2017.08.002.

The Relationship between Structural and Functional Brain Changes and Altered Emotion and Cognition in Chronic Low Back Pain: A Systematic Review of MRI and fMRI Studies.

Ng SK, Urquhart DM, Fitzgerald PB, Cicuttini FM, Hussain SM, Fitzgibbon BM. Clin J Pain. 2017 Jul 17. doi: 10.1097/AJP.0000000000000534.

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