Research

‘Spin’ in reports of clinical research

Kamal R Mahtani. Evid Based Med 2016;21:201-202. 13 October 2016 doi:10.1136/ebmed-2016-110570

“It is important to reinforce the importance of …”: ‘Hype’ in reports of randomized controlled trials

Neil Millar, Françoise Salager-Meyer, Brian Budgell. English for Specific Purposes. Volume 54, April 2019, Pages 139-151. DOI: 10.1016/j.esp.2019.02.004

2015 Updated Method Guideline for Systematic Reviews in the Cochrane Back and Neck Group.

http://www.ncbi.nlm.nih.gov/pubmed/26208232

A cross sectional observational study of research activity of allied health teams: is there a link with self-reported success, motivators and barriers to undertaking research?

Wenke RJ, Mickan S, Bisset L. BMC Health Serv Res. 2017 Feb 6;17(1):114. doi: 10.1186/s12913-017-1996-7.

A literature review reveals that trials evaluating treatment of non-specific low back pain use inconsistent criteria to identify serious pathologies and nerve root involvement

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360485/?tool=pmcentrez

A Pain Research Agenda for the 21st Century

http://www.jpain.org/article/S1526-5900%2814%2900913-4/fulltext

A standardized citation metrics author database annotated for scientific field.

Ioannidis JPA, Baas J, Klavans R, Boyack KW. PLoS Biol. 2019 Aug 12;17(8):e3000384. doi: 10.1371/journal.pbio.3000384.

Abstracts of low back pain trials are poorly reported, contain spin of information and are inconsistent with the full text: An overview study

Dafne Port Nascimento, Leonardo Oliveira Pena Costa, Gabrielle Zoldan Gonzalez, Christopher G. Maher, Anne M. Moseley. Archives of Physical Medicine and Rehabilitation. June 14, 2019. DOI: 10.1016/j.apmr.2019.03.024

Adverse events of exercise therapy in randomised controlled trials: a systematic review and meta-analysis.

Niemeijer A, Lund H, Stafne SN, Ipsen T, Goldschmidt CL, Jørgensen CT, Juhl CB. Br J Sports Med. 2019 Sep 28. pii: bjsports-2018-100461. doi: 10.1136/bjsports-2018-100461.

Allocation Concealment And Intention-To-Treat Analysis Do Not Influence The Treatment Effects Of Physical Therapy Interventions In Low Back Pain Trials: A Meta-Epidemiological Study

Oliveira de Almeida, Bruno Tirotti Saragiotto, Chris Maher, Leonardo Oliveira Pena Costa. Arch Phys Med Rehabil. January 30, 2019. DOI: 10.1016/j.apmr.2018.12.036

An Overview of the Practitioner Research and Collaboration Initiative (PRACI): a practice-based research network for complementary medicine.

Steel A, Sibbritt D, Schloss J, Wardle J, Leach M, Diezel H, Adams J. BMC Complement Altern Med. 2017 Feb 1;17(1):87. doi: 10.1186/s12906-017-1609-3

Bias due to lack of patient blinding in clinical trials. A systematic review of trials randomizing patients to blind and nonblind sub-studies

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258786

Classification of patients with incident non-specific low back pain: implications for research.

Norton G, McDonough CM, Cabral HJ, Shwartz M, Burgess JF Jr. Spine J. 2016 May 2015

COMPare: a prospective cohort study correcting and monitoring 58 misreported trials in real time

Ben Goldacre, Henry Drysdale, Aaron Dale, Ioan Milosevic, Eirion Slade, Philip Hartley, Cicely Marston, Anna Powell-Smith, Carl Heneghan and Kamal R. Mahtani. Trials 2019 20:118. 14 February 2019. DOI: 10.1186/s13063-019-3173-2

COMPare: Qualitative analysis of researchers’ responses to critical correspondence on a cohort of 58 misreported trials

Ben Goldacre, Henry Drysdale, Cicely Marston, Kamal R. Mahtani, Aaron Dale, Ioan Milosevic, Eirion Slade, Philip Hartley and Carl Heneghan. Trials 2019 20:124. 14 February 2019. DOI: 10.1186/s13063-019-3172-3

Comparisons against baseline within randomised groups are often used and can be highly misleading

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286439/?tool=pmcentrez

Compliance with requirement to report results on the EU Clinical Trials Register: cohort study and web resource

Ben Goldacre, senior clinical research fellow, Nicholas J DeVito, researcher, Carl Heneghan, professor, Francis Irving, software engineer, Seb Bacon, lead software engineer, Jessica Fleminger, research student, Helen Curtis, researcher. BMJ 2018; 362. 12 September 2018 doi: 10.1136/bmj.k3218

Considerations and methods for placebo controls in surgical trials (ASPIRE guidelines)

David J Beard, Marion K Campbell, Jane M Blazeby, Andrew J Carr, … Jonathan A Cook, et al. The Lancet, Volume 395, Issue 10226, 7–13 March 2020, Pages 756. DOI: 10.1016/S0140-6736(19)33137-X

Do clinicians understand the size of treatment effects? A randomized survey across 8 countries.

http://www.ncbi.nlm.nih.gov/pubmed/26504102

Does chiropractic truly understand research?

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154060/?tool=pmcentrez

Does involvement in a cohort study improve health and affect health inequalities? A natural experiment.

Quick A, Böhnke JR, Wright J, Pickett KE. BMC Health Serv Res. 2017 Jan 25;17(1):79. doi: 10.1186/s12913-017-2016-7.

Does source of funding and conflict of interest influence the outcome and quality of spinal research?

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940802

ECU convention 2017 research presentations

Alice Kongsted, Lise Hestbaek, Carlo Ammendolia, Pierre Côté, Danielle Southerst, Michael Schneider, Brian Budgell Et Al. Chiropractic & Manual Therapies. 2017 25(Suppl 1):36. 6 December 2017 Doi:10.1186/s12998-017-0166-7

Eight Out of Every Ten Abstracts of Low Back Pain Systematic Reviews Presented Spin and Inconsistencies With the Full Text: An Analysis of 66 Systematic Reviews.

Nascimento DP, Gonzalez GZ, Araujo AC, Moseley AM, Maher CG, Costa LOP. J Orthop Sports Phys Ther. 2019 Aug 23:1-34. doi: 10.2519/jospt.2020.8962.

Eligibility determination for clinical trials: development of a case review process at a chiropractic research centre

http://www.trialsjournal.com/content/15/1/406

Essential literature for the chiropractic profession: Results and implementation challenges from a survey of international chiropractic faculty.

Mansholt BA, Salsbury SA, Corber LG, Stites JS. J Chiropr Educ. 2017 Aug 2. doi: 10.7899/JCE-17-4.

Establishing the ACORN National Practitioner Database: Strategies to Recruit Practitioners to a National Practice-Based Research Network.

Adams J, Steel A, Moore C, Amorin-Woods L, Sibbritt D. J Manipulative Physiol Ther. 2016 Oct 4. pii: S0161-4754(16)30002-1. doi: 10.1016/j.jmpt.2016.08.006.

Expanding our perspectives on research in musculoskeletal science and practice

Roger Kerry. Musculoskeletal Science & Parctice. Oct 11, 2017. DOI:10.1016/j.msksp.2017.10.004

Extending conceptual frameworks: life course epidemiology for the study of back pain

http://www.biomedcentral.com/1471-2474/11/23

Failure to define low back pain as a disease or an episode renders research on causality unsuitable: results of a systematic review

Emad M. Ardakani, Charlotte Leboeuf-Yde and Bruce F. Walker Chiropractic & Manual Therapies 2018 26:1. 9 January 2018. Doi:10.1186/s12998-017-0172-9

Feasibility of using the Neuropen for temporal summation testing.

Aspinall SL, Leboeuf-Yde C, Etherington SJ, Walker BF. Pain Manag. 2019 Jun 19. doi: 10.2217/pmt-2018-0063.

Identifying subgroups of patients using latent class analysis: should we use a single-stage or a two-stage approach? A methodological study using a cohort of patients with low back pain.

Nielsen AM, Kent P, Hestbaek L, Vach W, Kongsted A. BMC Musculoskelet Disord. 2017 Feb 1;18(1):57. doi: 10.1186/s12891-017-1411-x.

Inclusion and exclusion criteria used in non-specific low back pain trials: a review of randomised controlled trials published between 2006 and 2012

Pål André Amundsen, David W. Evans, Dévan Rajendran, Philip Bright, Tom Bjørkli, Sandra Eldridge, Rachelle Buchbinder, Martin Underwood and Robert Froud. BMC Musculoskeletal Disorders 2018 19:113. 12 April 2018. Doi: 10.1186/s12891-018-2034-6

Interpreting Effectiveness Evidence in Pain: Short Tour of Contemporary Issues.

http://www.ncbi.nlm.nih.gov/pubmed/25929527

Introducing the new CONSORT extension for stepped-wedge cluster randomised trials.

Hemming K, Taljaard M, Grimshaw J. Trials. 2019 Jan 18;20(1):68. doi: 10.1186/s13063-018-3116-3.

Investigating causal mechanisms in randomised controlled trials.

Lee H, Herbert RD, Lamb SE, Moseley AM, McAuley JH. Trials. 2019 Aug 23;20(1):524. doi: 10.1186/s13063-019-3593-z.

It is time to replace publish or perish with get visible or vanish: opportunities where digital and social media can reshape knowledge translation

Christian J Barton, Mark A Merolli. BJSM. Nov 17. doi:10.1136/bjsports-2017-098367

Many randomized trials of physical therapy interventions are not adequately registered: a survey of 200 published trials.

http://www.ncbi.nlm.nih.gov/pubmed/23125281

Meta-analysis and the science of research synthesis.

Gurevitch J, Koricheva J, Nakagawa S, Stewart G. Nature. 2018 Mar 7;555(7695):175-182. doi: 10.1038/nature25753.

Model Simulations Challenge Reductionist Research Approaches to Studying Chronic Low Back Pain.

Cholewicki J, Pathak PK, Reeves NP, Popovich JM Jr. J Orthop Sports Phys Ther. 2019 Jun;49(6):477-481. doi: 10.2519/jospt.2019.8791.

New evidence pyramid

Murad MH, Asi N, Alsawas M, Alahdab F. Evid Based Med. 2016 Aug

Number Needed to Treat: Conveying the Likelihood of a Therapeutic Effect

Jeffrey L. Saver, MD; Roger J. Lewis, MD, PhD. JAMA. Published online February 7, 2019. doi:10.1001/jama.2018.21971

One in 11 Cochrane reviews are on rehabilitation interventions, according to pragmatic inclusion criteria developed by Cochrane Rehabilitation.

Magnus Levack WM, Rathore FA, Pollet J, Negrini S. Arch Phys Med Rehabil. 2019 Mar 1. pii: S0003-9993(19)30147-9. doi: 10.1016/j.apmr.2019.01.021.

Open access physical therapy journals: do predatory journals publish lower quality Randomized Controlled Trials?

Bianchini C, Cosentino C, Paci M, Baccini M. Arch Phys Med Rehabil. 2020 Jan 27. pii: S0003-9993(20)30024-1. doi: 10.1016/j.apmr.2019.12.012.

Overall confidence in the results of systematic reviews on exercise therapy for chronic low back pain: a cross-sectional analysis using the Assessing the Methodological Quality of Systematic Reviews (AMSTAR) 2 tool.

Almeida MO, Yamato TP, Parreira PDCS, Costa LOP, Kamper S, Saragiotto BT. Braz J Phys Ther. 2019 May 8. pii: S1413-3555(18)30599-9. doi: 10.1016/j.bjpt.2019.04.004.

Quality of musculoskeletal trials Methodological quality and statistical reporting of physical therapy randomized controlled trials relevant to musculoskeletal conditions.

Zoldan Gonzalez G, Moseley AM, Maher CG, Nascimento DP, da Cunha Menezes Costa L, Oliveira Pena Costa L. Arch Phys Med Rehabil. 2017 Sep 26. pii: S0003-9993(17)31097-3. doi: 10.1016/j.apmr.2017.08.485.

Quality of reporting of randomised controlled trials in chiropractic using the CONSORT checklist.

Karpouzis F, Bonello R, Pribicevic M, Kalamir A, Brown BT. Chiropr Man Therap. 2016 Jun

Quasi-experimental causality in neuroscience and behavioural research

Ioana E. Marinescu, Patrick N. Lawlor & Konrad P. Kording. Nature Human Behavior. 26 Nov 2018. Doi: 10.1038/s41562-018-0466-5

Rating the certainty in evidence in the absence of a single estimate of effect.

Murad MH, Mustafa RA, Schünemann HJ, Sultan S, Santesso N. Evid Based Med. 2017 Jun;22(3):85-87. doi: 10.1136/ebmed-2017-110668.

Rational and design of an individual participant data meta-analysis of spinal manipulative therapy for chronic low back pain-a protocol.

de Zoete A, de Boer MR, van Tulder MW, Rubinstein SM, Underwood M, Hayden JA, Kalter J, Ostelo R. Syst Rev. 2017 Jan 26;6(1):21. doi: 10.1186/s13643-017-0413-y.

Report of the NIH task force on research standards for chronic low back pain.

http://www.ncbi.nlm.nih.gov/pubmed/24887571

Reporting of results from network meta-analyses: methodological systematic review

http://www.bmj.com/content/348/bmj.g1741

Research capacity building frameworks for allied health professionals – a systematic review.

Matus J, Walker A, Mickan S. BMC Health Serv Res. 2018 Sep 15;18(1):716. doi: 10.1186/s12913-018-3518-7.

Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500524

Research priorities of the Canadian chiropractic profession: a consensus study using a modified Delphi technique

Simon D. French, Peter J. H. Beliveau, Paul Bruno, Steven R. Passmore, Jill A. Hayden, John Srbely and Greg N. Kawchuk. Chiropractic & Manual Therapies. Dec 17. Doi:10.1186/s12998-017-0169-4

Researching the Appropriateness of Care in the Complementary and Integrative Health Professions Part 3: Designing Instruments With Patient Input

Margaret D. Whitley, Ian D. Coulter, Ryan W. Gery, Ron D. Hays, Cathy Sherbourne, Patricia M. Herman, Lara G. Hilton. Journal of Manipulative and Physiological Therapeutics. June 27, 2019. DOI: 10.1016/j.jmpt.2019.02.006

Researching the Appropriateness of Care in the Complementary and Integrative Health Professions Part 4: Putting Practice Back Into Evidence-based Practice by Recruiting Clinics and Patients

Ian D. Coulter, Gursel R. Aliyev, Margaret D. Whitley, Lisa S. Kraus, Praise O. Iyiewuare, Ryan W. Gery, Lara G. Hilton, Patricia M. Herman. Journal of Manipulative and Physiological Therapeutics. June 18, 2019. DOI: 10.1016/j.jmpt.2019.02.007

Researching the Appropriateness of Care in the Complementary and Integrative Health Professions Part 5: Using Patient Records: Selection, Protection, and Abstraction

Carol P. Roth, Ian D. Coulter, Lisa S. Kraus, Gery W. Ryan, Gary Jacob, Joyce S. Marks, Eric L. Hurwitz, Howard Vernon, Paul G. Shekelle, Patricia M. Herman. Journal of Manipulative and Physiological Therapeutics. June 27, 2019. DOI: 10.1016/j.jmpt.2019.02.008

Retention of Blinding at Follow-Up in a Randomized Clinical Study Using a Sham-Control Cervical Manipulation Procedure for Neck Pain: Secondary Analyses From a Randomized Clinical Study

http://www.ncbi.nlm.nih.gov/pubmed/24011656

Size does matter, but it isn’t everything: the challenge of modest treatment effects in chronic pain clinical trials

Shannon M. Smith, Maurizio Fava, Mark P. Jensen, Omar B. Mbowe, Michael P. McDermott, Dennis C. Turk, Robert H. Dworkin. The Journal of Pain. September 30, 2019. DOI: 10.1016/j.jpain.2019.09.008

Specifying the target difference in the primary outcome for a randomised controlled trial: guidance for researchers

http://www.trialsjournal.com/content/16/1/12

Subjects no more: what happens when trial participants realize they hold the power?

http://www.bmj.com/content/348/bmj.g368

Systematic reviews of meta‐analyses: applications and limitations

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566156/?tool=pmcentrez

The blind leading the not so blind: a meta-analysis of blinding in pharmacological trials for chronic pain.

Colagiuri B, Sharpe L, Scott A. J Pain. 2018 Sep 21. pii: S1526-5900(18)30603-5. doi: 10.1016/j.jpain.2018.09.002.

The growth and increase of the number of journals focusing on Spine: a scientific blessing?

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940802

The n-of-1 clinical trial: the ultimate strategy for individualizing medicine?

Lillie EO, Patay B, Diamant J, Issell B, Topol EJ, Schork NJ. Per Med. 2011 Mar;8(2):161-173.

The New Agenda for Neck Pain Research: A Modified Delphi Study.

Silva PV, Costa LOP, Maher CG, Kamper SJ, Costa LDCM. J Orthop Sports Phys Ther. 2019 Jul 10:1-27. doi: 10.2519/jospt.2019.8704.

The Power of Low Back Pain Trials: A Systematic Review of Power, Sample Size, and Reporting of Sample Size Calculations over Time, in Trials Published between 1980 and 2012.

Froud R, Rajendran D, Patel S, Bright P, Bjørkli T, Eldridge S, Buchbinder R, Underwood M. Spine (Phila Pa 1976). 2016 Oct 25.

The Proposal to Lower P Value Thresholds to .005.

Ioannidis JPA. JAMA. 2018 Mar 22. doi: 10.1001/jama.2018.1536.

The Rehabilitation Treatment Specification System: Implications for improvements in research design, reporting, replication, and synthesis.

Van Stan JH, Dijkers MP, Whyte J, Hart T, Turkstra LS, Zanca J, Chen C. Arch Phys Med Rehabil. 2018 Sep 26. pii: S0003-9993(18)31313-3. doi: 10.1016/j.apmr.2018.09.112.

The research crisis in American institutions of complementary and integrative health: one proposed solution for chiropractic profession

Ian D. Coulter and Patricia M. Herman. Chiropractic & Manual Therapies 2019 27:32. 17 June 2019. DOI: 10.1186/s12998-019-0251-1

The Risk of Bias and Sample Size of Trials of Spinal Manipulative Therapy for Low Back and Neck Pain: Analysis and Recommendations

http://www.jmptonline.org/article/S0161-4754%2814%2900123-7/fulltext

Time to rethink the systematic review catechism? Moving from ‘what works’ to ‘what happens’

http://www.systematicreviewsjournal.com/content/4/1/36

Top 100 Cited Articles on Back Pain Research: A Citation Analysis.

Huang W, Wang L, Wang B, Yu L, Yu X. Spine (Phila Pa 1976). 2016 Nov 1;41(21):1683-1692.

Towards more credible shams for physical interventions: A Delphi survey.

Braithwaite FA, Walters JL, Moseley GL, Williams MT, McEvoy MP. Clin Trials. 2020 Mar 10:1740774520910365. doi: 10.1177/1740774520910365.

Towards more credible shams for physical interventions: A Delphi survey.

Braithwaite FA, Walters JL, Moseley GL, Williams MT, McEvoy MP. Clin Trials. 2020 Mar 10:1740774520910365. doi: 10.1177/1740774520910365.

Trusting systematic reviews and meta-analyses: all that glitters is not gold!

Weir A, Rabia S, Ardern C. British Journal of Sports Medicine 2016 sept. vol: 50 (18) pp: 1100-1101 DOI: 10.1136/bjsports-2015-095896

Understanding clinical reasoning in osteopathy: a qualitative research approach

http://chiromt.biomedcentral.com/articles/10.1186/s12998-016-0087-x

United States National Pain Strategy for Population Research: Concepts, Definitions and Pilot Data.

Von Korff M, Scher AI, Helmick C, Carter-Pokras O, Dodick D, Goulet J, Hamill-Ruth R, LeResche L, Porter L, Tait R, Terman G, Veasley C, Mackey S. J Pain. 2016 Jul

Updated Method Guideline for Systematic Reviews in the Cochrane Back and Neck Group.

http://www.ncbi.nlm.nih.gov/pubmed/26208232

Validation of a novel sham cervical manipulation procedure

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513586/?tool=pmcentrez

Why clinical trial outcomes fail to translate into benefits for patients

Carl Heneghan, Ben Goldacre and Kamal R. Mahtani BMC Trials. 14 March 2017 DOI: 10.1186/s13063-017-1870-2

Why Most Clinical Research Is Not Useful

Ioannidis, John. PLOS Medicine. 2016 June

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