SMT – Neurology

A pilot study of the manual force levels required to produce manipulation induced hypoalgesia.

A randomised, independent groups study investigating the sympathetic nervous system responses to two manual therapy treatments in patients with LBP.

Perry J, Green A, Singh S, Watson P. Man Ther. 2015 Dec;20(6):861-7. doi: 10.1016/j.math.2015.04.011.

Alterations in Cortical and Cerebellar Motor Processing in Subclinical Neck Pain Patients Following Spinal Manipulation

An investigation of the interrelationship between manipulative therapy-induced hypoalgesia and sympathoexcitation.

Attenuation Effect of Spinal Manipulation on Neuropathic and Postoperative Pain Through Activating Endogenous Anti-Inflammatory Cytokine Interleukin 10 in Rat Spinal Cord

Autonomic Effects of Spinal Manipulative Therapy: Systematic Review of Randomized Controlled Trials.

Araujo FX, Ferreira GE, Angellos RF, Stieven FF, Plentz RDM, Silva MF. J Manipulative Physiol Ther. 2019 Nov 23. pii: S0161-4754(18)30184-2. doi: 10.1016/j.jmpt.2018.12.005.

Basic Science Research Related to Chiropractic Spinal Adjusting: The State of the Art and Recommendations Revisited

Biomechanical and neurophysiological responses to spinal manipulation in patients with lumbar radiculopathy.

Brain Mechanisms of Anticipated Painful Movements and Their Modulation by Manual Therapy in Chronic Low Back Pain.

Ellingsen DM, Napadow V, Protsenko E, Mawla I, Kowalski MH, Swensen D, O’Dwyer-Swensen D, Edwards RR, Kettner N, Loggia ML. J Pain. 2018 Nov;19(11):1352-1365. doi: 10.1016/j.jpain.2018.05.012.

Central neuronal plasticity, low back pain and spinal manipulative therapy.

Changes in biochemical markers of pain perception and stress response after spinal manipulation.

Changes in pain sensitivity following spinal manipulation: A systematic review and meta-analysis

Changes in pressure pain threshold and temporal summation in rapid responders and non-rapid responders after lumbar spinal manipulation and sham: A secondary analysis in adults with low back pain

Sasha L. Aspinall, Charlotte Leboeuf-Yde, Sarah J. Etherington, Bruce F. Walker. Musculoskeletal Science and Practice. 26 February 2020. DOI: 10.1016/j.msksp.2020.102137

Characteristics of Paraspinal Muscle Spindle Response to Mechanically Assisted Spinal Manipulation: A Preliminary Report.

Reed WR, Pickar JG, Sozio RS, Liebschner MAK, Little JW, Gudavalli MR. J Manipulative Physiol Ther. 2017 Jun 17. pii: S0161-4754(17)30026-X. doi: 10.1016/j.jmpt.2017.03.006.

Commentary: we can tell where it hurts, but can we tell where the pain is coming from or where we should manipulate?

Comparison of two lumbar manual therapies on temporal summation of pain in healthy volunteers.

Penza CW, Horn ME, George SZ, Bishop MD. J Pain. 2017 Aug 8. pii: S1526-5900(17)30659-4. doi: 10.1016/j.jpain.2017.07.007.

Decreased Neurologic Pain Signature Activation Following Thoracic Spine Manipulation in Healthy Volunteers

Weber, T. Wager, J. Elliott, S. Mackey, … C. Sparks. The Journal of Pain. April 2019. DOI: 10.1016/j.jpain.2019.02.075v

Decreased spontaneous activity and altered evoked nociceptive response of rat thalamic submedius neurons to lumbar vertebra thrust.

Reed WR, Cranston JT, Onifer SM, Little JW, Sozio RS. Exp Brain Res. 2017 Jul 7. doi: 10.1007/s00221-017-5013-5.

Does Conservative Treatment Change the Brain in Patients with Chronic Musculoskeletal Pain? A Systematic Review.

Kregel J, Coppieters I, DePauw R, Malfliet A, Danneels L, Nijs J, Cagnie B, Meeus M. Pain Physician. 2017 Mar;20(3):139-154.

Effect of chiropractic manipulative therapy on reaction time in special operations forces military personnel: a randomized controlled trial.

DeVocht JW, Vining R, Smith DL, Long C, Jones T, Goertz C. Trials. 2019 Jan 3;20(1):5. doi: 10.1186/s13063-018-3133-2.

Effect of lumbar spinal manipulation on local and remote pressure pain threshold and pinprick sensitivity in asymptomatic individuals: A randomised trial

Sasha L. Dorron, Barrett E. Losco, Peter D. Drummond and Bruce F. Walker Chiropractic & Manual Therapies201624:47 DOI: 10.1186/s12998-016-0128-5

Effect of manual approaches with osteopathic modality on brain correlates of interoception: an fMRI study.

Cerritelli F, Chiacchiaretta P, Gambi F, Perrucci MG, Barassi G, Visciano C, Bellomo RG, Saggini R, Ferretti A. Sci Rep. 2020 Feb 21;10(1):3214. doi: 10.1038/s41598-020-60253-6

Effect of spinal manipulation on the development of history-dependent responsiveness of lumbar paraspinal muscle spindles in the cat

Effect of Spinal Manipulation Thrust Magnitude on Trunk Mechanical Thresholds of Lateral Thalamic Neurons

Effect of spinal manipulative treatment on cardiovascular autonomic control in patients with acute low back pain

Mohamed Younes, Karine Nowakowski, Benoit Didier-Laurent, Michel Gombert and François Cottin. Chiropractic & Manual Therapies. 2017 25:33. 4 December 2017. Doi:10.1186/s12998-017-0167-6

Effects of 12 Weeks of Chiropractic Care on Central Integration of Dual Somatosensory Input in Chronic Pain Patients: A Preliminary Study

Heidi Haavik, Imran Khan Niazi, Kelly Holt, Bernadette Murphy DOI:10.1016/j.jmpt.2016.10.002 JMPT February 10, 2017

Efficacy of Physical Therapy on Nociceptive Pain Processing Alterations in Patients with Chronic Musculoskeletal Pain: A Systematic Review and Meta-analysis.

Arribas-Romano A, Fernández-Carnero J, Molina-Rueda F, Angulo-Diaz-Parreño S, Navarro-Santana MJ. Pain Med. 2020 Feb 25. pii: pnz366. doi: 10.1093/pm/pnz366.

Elevated Production of Nociceptive CC Chemokines and sE-Selectin in Patients With Low Back Pain and the Effects of Spinal Manipulation: A Nonrandomized Clinical Trial.

Teodorczyk-Injeyan JA, McGregor M, Triano JJ, Injeyan SH. Clin J Pain. 2018 Jan;34(1):68-75. doi: 10.1097/AJP.0000000000000507.

Elevated Production of Nociceptive CC-chemokines and sE-selectin in Patients with Low Back Pain and the Effects of Spinal Manipulation: A Non-randomized Clinical Trial.

Teodorczyk-Injeyan JA, McGregor M, Triano JJ, Injeyan HS. Clin J Pain. 2017 Apr 19. doi: 10.1097/AJP.0000000000000507.

Evidence for decreased Neurologic Pain Signature activation following thoracic spinal manipulation in healthy volunteers and participants with neck pain

Kenneth A. Weber II, Tor D. Wager, Sean Mackey, James M. Elliott, … Cheryl L. Sparks. NeuroImage: Clinical. Volume 24, 2019, 102042. DOI: 10.1016/j.nicl.2019.102042

How big is the effect of spinal manipulation on the pressure pain threshold and for how long does it last? – secondary analysis of data from a systematic review

Margaux Honoré, Charlotte Leboeuf-Yde, Olivier Gagey and Niels Wedderkopp. Chiropractic & Manual Therapies. 201927:22. 24 April 2019. DOI: 10.1186/s12998-019-0240-4

Immediate changes in neck pain intensity and widespread pressure pain sensitivity in patients with bilateral chronic mechanical neck pain: a randomized controlled trial of thoracic thrust manipulation vs non-thrust mobilization.

Immediate effects from manual therapy: much ado about nothing?

Immediate effects of cervical mobilisations on global perceived effect, movement associated pain and neck kinematics in patients with non-specific neck pain. A double blind placebo randomised controlled trial

Ion Lascurain-Aguirrebeña, Di J. Newham, Xabat Casado-Zumeta, Aitana Lertxundi, Duncan J. Critchley. Musculoskeletal Science and Practice. October 13, 2018. DOI: 10.1016/j.msksp.2018.10.003

Immediate effects of spinal manipulation on nitric oxide, substance P and pain perception.

Immediate effects of spinal manipulation on thermal pain sensitivity: an experimental study

Immediate effects of spinal manipulative therapy on regional antinociceptive effects in myofascial tissues in healthy young adults.

Immediate reduction in temporal sensory summation after thoracic spinal manipulation

Impact of Spinal Manipulation on Lower Extremity Motor Control in Lumbar Spinal Stenosis Patients: A Small-Scale Assessor-Blind Randomized Clinical Trial

Steven R. Passmore, Michael G. Johnson, Saleh M. Aloraini, Stephan Cooper, Mina Aziz, Cheryl M. Glazebrook. J Manipulative Physiol Ther. April 5, 2019. DOI: 10.1016/j.jmpt.2018.10.002

In the spine or in the brain? Recent advances in pain neuroscience applied in the intervention for low back pain.

Nijs J, Clark J, Malfliet A, Ickmans K, Voogt L, Don S, den Bandt H, Goubert D, Kregel J, Coppieters I, Dankaerts W. Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 107(5):108-115.

Increased Voluntary Activation of the Elbow Flexors Following a Single Session of Spinal Manipulation in a Subclinical Neck Pain Population.

Kingett M, Holt K, Niazi IK, Nedergaard RW, Lee M, Haavik H. Brain Sci. 2019 Jun 12;9(6). pii: E136. doi: 10.3390/brainsci9060136.

Influence of Spinal Manipulation on Muscle Spasticity and Manual Dexterity in Participants With Cerebral Palsy: Randomized Controlled Trial

Oleh Kachmar, Anna Kushnir, Oles Matiushenko, Marko Hasiuk. J. Chiro Med. August 28, 2018. DOI: 10.1016/j.jcm.2018.03.004

Investigating the Effects of Chiropractic Spinal Manipulation on EEG in Stroke Patients.

Navid MS, Niazi IK, Lelic D, Nedergaard RB, Holt K, Amjad I, Drewes AM, Haavik H. Brain Sci. 2020 Apr 27;10(5). pii: E253. doi: 10.3390/brainsci10050253.

Is manipulative therapy more effective than sham manipulation in adults?: a systematic review and meta-analysis

Low threshold unmyelinated mechanoafferents can modulate pain.

Habig K, Schänzer A, Schirner W, Lautenschläger G, Dassinger B, Olausson H, Birklein F, Gizewski ER, Krämer HH. BMC Neurol. 2017 Sep 15;17(1):184. doi: 10.1186/s12883-017-0963-6.

Manipulation-induced hypoalgesia in musculoskeletal pain populations: a systematic critical review and meta-analysis

Sasha L. Aspinall, Charlotte Leboeuf-Yde, Sarah J. Etherington and Bruce F. Walker. Chiropractic & Manual Therapies201927:7. 29 January 2019. Doi: 10.1186/s12998-018-0226-7

Manual therapy prevents onset of nociceptor activity, sensorimotor dysfunction, and neural fibrosis induced by a volitional repetitive task.

Bove GM, Delany SP, Hobson L, Cruz GE, Harris MY, Amin M, Chapelle SL, Barbe MF. Pain. 2018 Nov 16. doi: 10.1097/j.pain.0000000000001443.

Mechanical stimulation of cervical vertebrae modulates the discharge activity of ventral tegmental area neurons and dopamine release in the nucleus accumbens

Kyle B. Bills, J.Daniel Obray, Travis Clarke, Mandy Parsons, … Scott C. Steffensen. Brain Stimulation. 4 December 2019. DOI: 10.1016/j.brs.2019.11.012

Mechanism of Action of Spinal Mobilizations: A Systematic Review.

Modeling the nonlinear cortical response in EEG evoked by wrist joint manipulation.

Vlaar MP, Birpoutsoukis G, Lataire J, Schoukens M, Schouten AC, Schoukens J, van der Helm FCT. IEEE Trans Neural Syst Rehabil Eng. 2017 Sep 13. doi: 10.1109/TNSRE.2017.2751650.

Motor Neuron Excitability Attenuation as a Sequel to Lumbosacral Manipulation in Subacute Low Back Pain Patients and Asymptomatic Adults: A Cross-Sectional H-Reflex Study.

Dishman JD, Burke JR, Dougherty P. J Manipulative Physiol Ther. 2018 Jul 9. pii: S0161-4754(17)30170-7. doi: 10.1016/j.jmpt.2017.10.015.

Neural Responses to the Mechanical Parameters of a High-Velocity, Low-Amplitude Spinal Manipulation: Effect of Preload Parameters

Neuro-Endocrine Response Following a Thoracic Spinal Manipulation in Healthy Men.

Sampath KK, Botnmark E, Mani R, Cotter JD, Katare R, Munasinghe PE, Tumilty S. J Orthop Sports Phys Ther. 2017 Jul 13:1-34. doi: 10.2519/jospt.2017.7348.

Neuromechanical characterization of in vivo lumbar spinal manipulation. Part I. Vertebral motion.

Neuromechanical characterization of in vivo lumbar spinal manipulation. Part II. Neurophysiological response.

Neurophysiological effects of spinal manipulation

No difference in pressure pain threshold and temporal summation after lumbar spinal manipulation compared to sham: A randomised controlled trial in adults with low back pain

Sasha L. Aspinall, Angela Jacques, Charlotte Leboeuf-Yde, Sarah J. Etherington, Bruce F. Walker. Musculoskeletal Science and Practice. 31 May 2019. DOI: 10.1016/j.msksp.2019.05.011

Physiological responses to spinal manipulation therapy: investigation of the relationship between electromyographic responses and peak force.

Relationship between Biomechanical Characteristics of Spinal Manipulation and Neural Responses in an Animal Model: Effect of Linear Control of Thrust Displacement versus Force, Thrust Amplitude, Thrust Duration, and Thrust Rate

Response of muscle proprioceptors to spinal manipulative-like loads in the anesthetized cat.

Role for Endocannabinoids in Spinal Manipulative Therapy Analgesia?

Onifer SM, Sozio RS, Long CR. Evid Based Complement Alternat Med. 2019 Jul 15;2019:2878352. doi: 10.1155/2019/2878352.

Short-term effect of spinal manipulation on pain perception, spinal mobility, and full height recovery in male subjects with degenerative disk disease: a randomized controlled trial.

Spinal manipulation alters electromyographic activity of paraspinal muscles: a descriptive study.

Spinal manipulation does not affect pressure pain thresholds in the absence of neuromodulators: A randomized controlled trial.

Jordon MK, Beattie PF, D’Urso S, Scriven S. J Man Manip Ther. 2017 Sep;25(4):172-181. doi: 10.1080/10669817.2016.1230352.

Spinal manipulation force and duration affect vertebral movement and neuromuscular responses.

Spinal Manipulation Therapy Improves Tactile Allodynia and Peripheral Nerve Functionality and Modulates Blood Oxidative Stress Markers in Rats Exposed to Knee-Joint Immobilization

Felipe C.K. Duarte, Carolina Kolberg, Ana Paula K. Riffel, Jessica A. Souza, Adriane Belló-Klein, Wania A. Partata. Journal of Manipulative and Physiological Therapeutics. July 30, 2019. DOI: 10.1016/j.jmpt.2018.11.023

Spinal Manipulation Therapy Improves Tactile Allodynia and Peripheral Nerve Functionality and Modulates Blood Oxidative Stress Markers in Rats Exposed to Knee-Joint Immobilization

Felipe C.K. Duarte, Carolina Kolberg, Ana Paula K. Riffel, Jessica A. Souza, Adriane Belló-Klein, Wania A. Partata. Journal of Manipulative and Physiological Therapeutics. July 30, 2019. DOI: 10.1016/j.jmpt.2018.11.023

Spinal manipulation therapy: is it all about the brain? A current review of the neurophysiological effects of manipulation

Giles Gyer, Jimmy Michael, James Inklebarger, Jaya Shanker Tedla. Journal of Integrative Medicine. 9 May 2019. DOI: 10.1016/j.joim.2019.05.004

Spinal manipulation therapy: Is it all about the brain? A current review of the neurophysiological effects of manipulation.

Gyer G, Michael J, Inklebarger J, Tedla JS. J Integr Med. 2019 May 9. pii: S2095-4964(19)30059-7. doi: 10.1016/j.joim.2019.05.004.

Spinal Manipulative Therapy and Somatosensory Activation

Spinal manipulative therapy reduces inflammatory cytokines but not substance P production in normal subjects.

Spinal Manipulative Therapy–Specific Changes in Pain Sensitivity in Individuals With Low Back Pain

Spinal reflex attenuation associated with spinal manipulation.

Spinal reflex excitability changes after cervical and lumbar spinal manipulation: a comparative study.

Stimulation parameters define the effectiveness of burst spinal cord stimulation in a rat model of neuropathic pain.

Subclinical recurrent neck pain and its treatment impacts motor training-induced plasticity of the cerebellum and motor cortex.

Baarbé JK, Yielder P, Haavik H, Holmes MWR, Murphy BA. PLoS One. 2018 Feb 28;13(2):e0193413. doi: 10.1371/journal.pone.0193413.

Tactile Perception of Pressure and Volitional Thrust Intensity Modulate Spinal Manipulation Dose Characteristics.

Passmore SR, Gelley GM, Malone Q, MacNeil BJ. J Manipulative Physiol Ther. 2019 Jul 1. pii: S0161-4754(18)30126-X. doi: 10.1016/j.jmpt.2018.11.017.

The acute effects of joint manipulative techniques on markers of autonomic nervous system activity: a systematic review and meta-analysis of randomized sham-controlled trials

Mathieu Picchiottino, Charlotte Leboeuf-Yde, Olivier Gagey and David M. Hallman. Chiropractic & Manual Therapies201927:17. 12 March 2019. DOI: 10.1186/s12998-019-0235-1

The effect of a single spinal manipulation on cardiovascular autonomic activity and the relationship to pressure pain threshold: a randomized, cross-over, sham-controlled trial.

Picchiottino M, Honoré M, Leboeuf-Yde C, Gagey O, Cottin F, Hallman DM. Chiropr Man Therap. 2020 Jan 20;28:7. doi: 10.1186/s12998-019-0293-4.

The effect of manual therapy on gastrocnemius muscle stiffness in healthy individuals.

Albin SR, Koppenhaver SL, Bailey B, Blommel H, Fenter B, Lowrimore C, Smith AC, McPoil TG. Foot (Edinb). 2019 Jan 11;38:70-75. doi: 10.1016/j.foot.2019.01.006.

The effect of manual therapy to the thoracic spine on pain-free grip and sympathetic activity in patients with lateral epicondylalgia humeri. A randomized, sample sized planned, placebo-controlled, patient-blinded monocentric trial.

Zunke P, Auffarth A, Hitzl W, Moursy M. BMC Musculoskelet Disord. 2020 Mar 24;21(1):186. doi: 10.1186/s12891-020-3175-y.

The effect of spinal manipulation on brain neurometabolites in chronic nonspecific low back pain patients: a randomized clinical trial.

Didehdar D, Kamali F, Yoosefinejad AK, Lotfi M. Ir J Med Sci. 2019 Nov 26. doi: 10.1007/s11845-019-02140-2.

The effect of spinal manipulation on deep experimental muscle pain in healthy volunteers

The effect of spinal manipulative therapy on heart rate variability and pain in patients with chronic neck pain: a randomized controlled trial.

Galaasen Bakken A, Axén I, Eklund A, O’Neill S. Trials. 2019 Oct 12;20(1):590. doi: 10.1186/s13063-019-3678-8.

The effects of a single session of chiropractic care on strength, cortical drive, and spinal excitability in stroke patients

Kelly Holt, Imran Khan Niazi, Heidi Haavik, et al. Scientific Reportsvolume 9, Article 2673, 25 Jan 2019. DOI: 10.1038/s41598-019-39577-5

The immediate and 24-hour follow-up effect of unilateral lumbar Z-joint mobilisation on posterior chain neurodynamics

The immediate effect of osteopathic cervical spine mobilization on median nerve mechanosensitivity: A triple-blind, randomized, placebo-controlled trial

Gary Whelan, Ross Johnston, Charles Millward, Darren J. Edwards. J.Bodywork and Movt. May 18, 2017 DOI:10.1016/j.jbmt.2017.05.009

The influence of placebo analgesia manipulations on pain report, the nociceptive flexion reflex, and autonomic responses to pain

Jamie L. Rhudy, Yvette M. Güereca, Bethany L. Kuhn, Shreela Palit, Magne Arve Flaten. Pain .J . May 11, 2018. DOI: 10.1016/j.jpain.2018.04.012

The Mechanisms of Manual Therapy in the Treatment of Musculoskeletal Pain: A Comprehensive Model

The neurophysiological effects of a single session of spinal joint mobilization: does the effect last?

The regional effect of spinal manipulation on the pressure pain threshold in asymptomatic subjects: a systematic literature review

Margaux Honoré, Charlotte Leboeuf-Yde and Olivier Gagey. Chiropractic & Manual Therapies201826:11. 19 April 2018. doi:10.1186/s12998-018-0181-3

The role of preload forces in spinal manipulation: experimental investigation of kinematic and electromyographic responses in healthy adults.

The Variation of Cross-Sectional Area of the Sciatic Nerve in Flexion-Distraction Technique: A Cross-Sectional Study

Maria Alice Mainenti Pagnez, Leticia Amaral Corrêa, Renato Santos Almeida, Ney Armando Meziat-Filho, Stephanie Mathieson, François Ricard, Leandro Alberto Calazans Nogueira. Journal of Manipulative and Physiological Therapeutics. April 25, 2019. DOI: 10.1016/j.jmpt.2019.03.003

Understanding inhibitory mechanisms of lumbar spinal manipulation using H-reflex and F-wave responses: a methodological approach.

Unravelling functional neurology: a scoping review of theories and clinical applications in a context of chiropractic manual therapy

Anne-Laure Meyer, Amanda Meyer, Sarah Etherington and Charlotte Leboeuf-Yde Chiropractic & Manual Therapies. 18 July 2017. DOI: 10.1186/s12998-017-0151-1

Unravelling functional neurology: does spinal manipulation have an effect on the brain? – a systematic literature review

Anne-Laure Meyer, Michel-Ange Amorim, Martin Schubert, Petra Schweinhardt and Charlotte Leboeuf-Yde. Chiropractic & Manual Therapies 2019 27:60. 2 October 2019. DOI: 10.1186/s12998-019-0265-8

What is the effect of spinal manipulation on the pressure pain threshold in young, asymptomatic subjects? A randomized placebo-controlled trial, with a cross-over design.

Honoré M, Picchiottino M, Wedderkopp N, Leboeuf-Yde C, Gagey O. Chiropr Man Therap. 2020 Feb 7;28(1):6. doi: 10.1186/s12998-020-0296-1.

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