Immune System

Physical disuse contributes to widespread chronic mechanical hyperalgesia, tactile allodynia, and cold allodynia through neurogenic inflammation and spino-parabrachio-amygdaloid pathway activation. Ohmichi Y, Ohmichi M, Tashima R, Osuka K, Fukushige K, Kanikowska D, Fukazawa Y, Yawo H, Tsuda M, Naito M, Nakano T. Pain. 2020 Mar 13. doi: 10.1097/j.pain.0000000000001867. The compelling link between physical activity and the body’s defense system. Nieman DC, Wentz LM. J Sport Health Sci. 2019 May;8(3):201-217. doi: 10.1016/j.jshs.2018.09.009. A systematic review of the role of inflammatory biomarkers in acute, subacute and chronic non-specific low back pain  Patrick Morris, Kareem Ali, Mackenzie Merritt, Joey Pelletier and Luciana G Macedo. BMC Musculoskeletal Disorders 2020 21:142. 3 March 2020. DOI: 10.1186/s12891-020-3154-3 Association between Inflammatory Biomarkers and Non-specific Low Back Pain: A Systematic Review. Lim YZ, Wang Y, Cicuttini FM, Hughes HJ, Chou L, Urquhart DM, Ong PX, Hussain SM. Clin J Pain. 2020 Jan 27. doi: 10.1097/AJP.0000000000000810. Microbiota impacts on chronic inflammation and metabolic syndromerelated cognitive dysfunction. Arnoriaga-Rodríguez M, Fernández-Real JM. Rev Endocr Metab Disord. 2019 Dec;20(4):473-480. doi: 10.1007/s11154-019-09537-5. Biological motion during inflammation in humans. Lasselin J, Sundelin T, Wayne PM, Olsson MJ, Paues Göranson S, Axelsson J, Lekander M. Brain Behav Immun. 2019 Nov 27. pii: S0889-1591(19)30642-7. doi: 10.1016/j.bbi.2019.11.019. Mechanoflammation in osteoarthritis pathogenesis. Vincent TL. Semin Arthritis Rheum. 2019 Dec;49(3S):S36-S38. doi: 10.1016/j.semarthrit.2019.09.018. A Mediational Analysis of Stress, Inflammation, Sleep, and Pain in Acute Musculoskeletal Trauma. Walton DM, Pourkazemi F, Ghodrati M, Elliott JM. Clin J Pain. 2019 Dec 10. doi: 10.1097/AJP.0000000000000790. Chronic inflammation in the etiology of disease across the life span. Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM. Nat Med. 2019 Dec;25(12):1822-1832. doi: 10.1038/s41591-019-0675-0. Stress and the brain-gut axis in functional and chronic-inflammatory gastrointestinal diseases: A transdisciplinary challenge. Labanski A, Langhorst J, Engler H, Elsenbruch S. Psychoneuroendocrinology. 2019 Nov 2;111:104501. doi: 10.1016/j.psyneuen.2019.104501. Characterization of neuroinflammation and periphery-to-CNS inflammatory cross-talk in patients with disc herniation and degenerative disc disease. Palada V, Ahmed AS, Finn A, Berg S, Svensson CI, Kosek E. Brain Behav Immun. 2019 Jan;75:60-71. doi: 10.1016/j.bbi.2018.09.010. Mediation of the Acute Stress Response by the Skeleton. Berger JM, Singh P, Khrimian L, Morgan DA, Chowdhury S, Arteaga-Solis E, Horvath TL, Domingos AI, Marsland AL, Kumal Yadav V, Rahmouni K, Gao XB, Karsenty G. Cell Metab. 2019 Sep 4. pii: S1550-4131(19)30441-3. doi: 10.1016/j.cmet.2019.08.012. Non-specific Low Back Pain: Inflammatory Profiles of Patients with Acute and Chronic Pain. Teodorczyk-Injeyan JA, Triano JJ, Injeyan HS. Clin J Pain. 2019 Jul 5. doi: 10.1097/AJP.0000000000000745. Disease Specific Autoantibodies in Idiopathic Inflammatory Myopathies. Stuhlmüller B, Schneider U, González-González JB, Feist E. Front Neurol. 2019 May 8;10:438. doi: 10.3389/fneur.2019.00438. A cross talk between dysbiosis and gut-associated immune system governs the development of inflammatory arthropathies Alexander Kalinkovich, Gregory Livshits. Seminars in Arthritis and Rheumatism. 31 May 2019. DOI: 10.1016/j.semarthrit.2019.05.007 Prevalence of inflammatory posterior arch abnormalities on lumbar spine MRI in spondyloarthritis patients compared with low back pain patients. Braun H, Geniez C, Degboe Y, Constantin A, Cantagrel A, Nigon D, Sans N, Faruch-Bilfeld M, Ruyssen-Witrand A. Eur Radiol. 2019 May 22. doi: 10.1007/s00330-019-06231-7. Inflammatory biomarkers do not distinguish between patients with sciatica and referred leg pain within a primary care population: results from a nested study within the ATLAS cohort. Hider SL, Konstantinou K, Hay EM, Glossop J, Mattey DL. BMC Musculoskelet Disord. 2019 May 10;20(1):202. doi: 10.1186/s12891-019-2604-2. Neuroimmune interactions in chronic pain – an interdisciplinary perspective. Hore Z, Denk F. Brain Behav Immun. 2019 Apr 25. pii: S0889-1591(18)31174-7. doi: 10.1016/j.bbi.2019.04.033. Inflammatory biomarkers in patients with sciatica: a systematic review. Jungen MJ, Ter Meulen BC, van Osch T, Weinstein HC, Ostelo RWJG. BMC Musculoskelet Disord. 2019 Apr 9;20(1):156. doi: 10.1186/s12891-019-2541-0. Stress and inflammation – The need to address the gap in the transition between acute and chronic stress effects. Rohleder N. Psychoneuroendocrinology. 2019 Feb 20. pii: S0306-4530(18)30695-4. doi: 10.1016/j.psyneuen.2019.02.021. Pain and immunity: implications for host defence. Baral P, Udit S, Chiu IM. Nat Rev Immunol. 2019 Mar 15. doi: 10.1038/s41577-019-0147-2. Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study. Walker KA, Gottesman RF, Wu A, Knopman DS, Gross AL, Mosley TH Jr, Selvin E, Windham BG. Neurology. 2019 Feb 13. pii: 10.1212/WNL.0000000000007094. doi: 10.1212/WNL.0000000000007094. Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain. Matsuda M, Huh Y, Ji RR. J Anesth. 2018 Nov 17. doi: 10.1007/s00540-018-2579-4. Elevated inflammatory cytokine expression in CSF from patients with symptomatic thoracic disc herniations correlates with increased pain scores. Andrade P, Cornips EMJ, Sommer C, Daemen MA, Visser-Vandewalle V, Hoogland G. Spine J. 2018 Aug 1. pii: S1529-9430(18)31082-9. doi: 10.1016/j.spinee.2018.07.023. Multiple confounders influence the association between low-grade systemic inflammation and musculoskeletal pain. A call for a prudent interpretation of the literature. Lutke Schipholt IJ, Scholten-Peeters GGM, Bontkes HJ, Coppieters MW. Spine J. 2018 Jul 25. pii: S1529-9430(18)31036-2. doi: 10.1016/j.spinee.2018.07.019. The association between pro-inflammatory biomarkers and nonspecific low back pain: a systematic review. van den Berg R, Jongbloed EM, de Schepper EIT, Bierma-Zeinstra SMA, Koes BW, Luijsterburg PAJ. Spine J. 2018 Jun 27. pii: S1529-9430(18)30628-4. doi: 10.1016/j.spinee.2018.06.349. Association of Stress-Related Disorders With Subsequent Autoimmune Disease. Song H, Fang F, Tomasson G, Arnberg FK, Mataix-Cols D, Fernández de la Cruz L, Almqvist C, Fall K, Valdimarsdóttir UA. JAMA. 2018 Jun 19;319(23):2388-2400. doi: 10.1001/jama.2018.7028. An Inflammation-Centric View of Neurological Disease: Beyond the Neuron. Skaper SD, Facci L, Zusso M, Giusti P. Front Cell Neurosci. 2018 Mar 21;12:72. doi: 10.3389/fncel.2018.00072. Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity. Collins KH, Herzog W, MacDonald GZ, Reimer RA, Rios JL, Smith IC, Zernicke RF, Hart DA. Front Physiol. 2018 Feb 23;9:112. doi: 10.3389/fphys.2018.00112. Neuroinflammation and Central Sensitization in Chronic and Widespread Pain. Ji RR, Nackley A, Huh Y, Terrando N, Maixner W. Anesthesiology. 2018 Feb 19. doi: 10.1097/ALN.0000000000002130. Clinical evolution of patients with new-onset inflammatory back pain: a population-based cohort study. Wang R, Crowson CS, Wright K, Ward MM. Arthritis Rheumatol. 2018 Feb 22. doi: 10.1002/art.40460. Inflammation in the pathophysiology of neuropathic pain. Sommer C, Leinders M, Üçeyler N. Pain. 2018 Mar;159(3):595-602. doi: 10.1097/j.pain.0000000000001122. Neuroinflammation of the spinal cord and nerve roots in chronic radicular pain patients. Albrecht D, Ahmed S, Kettner N, Borra R, Cohen-Adad J, Deng H, Houle T, Opalacz A, Roth S, Melo MV, Chen L, Mao J, Hooker J, Loggia ML, Zhang Y. Pain. 2018 Feb 5. doi: 10.1097/j.pain.0000000000001171. Cytokine Involvement in Biological Inflammation Related to Degenerative Disorders of the Intervertebral Disk: A Narrative Review Christopher M. De Geer. J Chiropractic Medicine. February 4, 2018.  DOI: 10.1016/j.jcm.2017.09.003 Immune Cytokines and Their Receptors in Inflammatory Pain. Cook AD, Christensen AD, Tewari D, McMahon SB, Hamilton JA. Trends Immunol. 2018 Jan 12. pii: S1471-4906(17)30242-9. doi: 10.1016/j.it.2017.12.003. Inflammatory biomarkers of low back pain and disc degeneration: a review. Khan AN, Jacobsen HE, Khan J, Filippi CG, Levine M, Lehman RA Jr, Riew KD, Lenke LG, Chahine NO. Ann N Y Acad Sci. 2017 Dec;1410(1):68-84. doi: 10.1111/nyas.13551. Elevated Production of Nociceptive CC Chemokines and sE-Selectin in Patients With Low Back Pain and the Effects of Spinal Manipulation: A Nonrandomized Clinical Trial. Teodorczyk-Injeyan JA, McGregor M, Triano JJ, Injeyan SH. Clin J Pain. 2018 Jan;34(1):68-75. doi: 10.1097/AJP.0000000000000507. Cytokines in tendon disease: A Systematic Review. Morita W, Dakin SG, Snelling SJB, Carr AJ. Bone Joint Res. 2017 Dec;6(12):656-664. doi: 10.1302/2046-3758.612.BJR-2017-0112.R1. Sense and Immunity: Context-Dependent Neuro-Immune Interplay. Foster SL, Seehus CR, Woolf CJ, Talbot S. Front Immunol. 2017 Nov 3;8:1463. doi: 10.3389/fimmu.2017.01463. eCollection 2017. Neuroimmune expression in hip osteoarthritis: a systematic review. da Silva MR, Linhares D, Vasconcelos DM, Alves CJ, Neves N, Costa G, Lamghari M. BMC Musculoskelet Disord. 2017 Sep 11;18(1):394. doi: 10.1186/s12891-017-1755-2. Impact of Inflammation and Anti-inflammatory Modalities on Skeletal Muscle Healing: From Fundamental Research to the Clinic. Duchesne E, Dufresne SS, Dumont NA. Phys Ther. 2017 Aug 1;97(8):807-817. doi: 10.1093/ptj/pzx056. [EXPRESS] Immune System Involvement in Specific Pain Conditions. Totsch SK, Sorge RE. Mol Pain. 2017 Jan-Dec;13:1744806917724559. doi: 10.1177/1744806917724559. Inflammatory pain reduces C fibre activity-dependent slowing in a sex dependent manner, amplifying nociceptive input to the spinal cord. Dickie AC, McCormick B, Lukito V, Wilson KL, Torsney C. J Neurosci. 2017 Jun 2. pii: 3816-16. doi: 10.1523/JNEUROSCI.3816-16.2017. Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation. Pinho-Ribeiro FA, Verri WA Jr, Chiu IM. Trends Immunol. 2017 Jan;38(1):5-19. doi: 10.1016/j.it.2016.10.001. Epub 2016 Oct 25. Stress and Alterations in Bones: An Interdisciplinary Perspective. Wippert PM, Rector M, Kuhn G, Wuertz-Kozak K. Front Endocrinol (Lausanne). 2017 May 1;8:96. doi: 10.3389/fendo.2017.00096. Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain. Klyne DM, Barbe MF, Hodges PW. Brain Behav Immun. 2017 Feb;60:84-92. doi: 10.1016/j.bbi.2016.10.003. Cyclic Mechanical Loading Enhances Transport of Antibodies Into Articular Cartilage. DiDomenico CD, Xiang Wang Z, Bonassar LJ. J Biomech Eng. 2017 Jan 1;139(1). doi: 10.1115/1.4035265. Postrehabilitation Functional Improvements in Patients With Inflammatory Myopathies: The Results of a Randomized Controlled Trial. Tiffreau V, Rannou F, Kopciuch F, Hachulla E, Mouthon L, Thoumie P, Sibilia J, Drumez E, Thevenon A. Arch Phys Med Rehabil. 2016 Oct 24. pii: S0003-9993(16)31163-7. doi: 10.1016/j.apmr.2016.09.125. Sex differences in neuroimmunity and pain. Rosen S, Ham B, Mogil JS. J Neurosci Res. 2017 Jan 2;95(1-2):500-508. doi: 10.1002/jnr.23831. Acute colitis chronically alters immune infiltration mechanisms and sensory neuro-immune interactions. Campaniello MA, Mavrangelos C, Eade S, Harrington AM, Blackshaw LA, Brierley SM, Smid SD, Hughes PA. Brain Behav Immun. 2016 Nov 15. pii: S0889-1591(16)30517-7. doi: 10.1016/j.bbi.2016.11.015. Pain mechanisms and ultrasonic inflammatory activity as prognostic factors in patients with psoriatic arthritis: protocol for a prospective, exploratory cohort study. Højgaard P, Christensen R, Dreyer L, Mease P, Wit Md, Skov L, Glintborg B, Christensen AW, Ballegaard C, Bliddal H, Bukhave K, Bartels EM, Amris K, Ellegaard K, Kristensen LE. BMJ Open. 2016 Apr 15 Association Between the Plasma Levels of Mediators of Inflammation With Pain and Disability in the Elderly With Acute Low Back Pain: Data From the Back Complaints in the Elders (BACE)-Brazil Study. http://www.ncbi.nlm.nih.gov/pubmed/26571172  Crosstalk between the nociceptive and immune systems in host defence and disease. http://www.ncbi.nlm.nih.gov/pubmed/26087680  Immune mediators of chronic pelvic pain syndrome. http://www.ncbi.nlm.nih.gov/pubmed/24686526  Fatigue in chronic inflammation – a link to pain pathways http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593220/?tool=pmcentrez 

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